![]() However, clusters related to the fibrosis process were common in lung and skin tissues. In addition, clusters associated with inflammation and immunity were common in the three investigated tissues. Analysis revealed that the tumor necrosis factor (TNF) signaling pathway was enriched significantly in the three investigated tissues as a common pathway. ResultsĪ total of 12, 2, and 4 functional clusters from 619, 52, and 119 DEGs were determined in the lung, peripheral blood mononuclear cell (PBMC), and skin tissues, respectively. Enrichr, a gene list enrichment analysis tool, was utilized for the functional enrichment of clusters. Then, functional clusters in PPI networks were determined. DEGs were mapped to the search tool for retrieval of interacting genes (STRING) to acquire protein–protein interaction (PPI) networks. MethodsĪn integrative gene expression analysis of ten independent microarray datasets of three tissues was conducted to identify differentially expressed genes (DEGs). This study intended to investigate the common and tissue-specific pathways involved in different tissues of SSc patients. The mechanisms underlying tissue pathology in SSc have not been entirely understood. ![]() Systemic sclerosis (SSc), a multi-organ disorder, is characterized by vascular abnormalities, dysregulation of the immune system, and fibrosis.
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